Table 2.
Effects of papaya on body weight, liver weight, hepatic lipid contents and liver damage indices in high fat diet induced obesity in rats
|
|
C
|
HFD
|
HFL
|
HFH
|
| Initial weight (g) | 218.0 ± 12.18 | 236.5 ± 13.58 | 215.5 ± 14.01 | 221.8 ± 14.29 |
| Body weight at week 8 (g) | 398.6 ± 9.462 | 457.6 ± 18.93a | 462.9 ± 17.11a | 454.9 ± 7.584a |
| Body weight at week 12 (g) | 465.83 ± 11.13 | 536 ± 33.24c | 509.33 ± 33.57a | 471.33 ± 15.04e |
| Liver weight (% of body weight) | 2.66 ± 0.13 | 4.46 ± 0.3c | 4.49 ± 0.51c | 4.33 ± 0.26c |
| Hepatic triglycerides (mg/dL) | 140.60 ± 13.95 | 211.00 ± 26.25a | 172.50 ± 7.89 | 152.20 ± 12.68d |
| Hepatic cholesterol (mg/dL) | 74.30 ± 5.58 | 152.60 ± 9.44c | 112.40 ± 7.96b,e | 92.38 ± 6.66f |
| Serum ALT (U/mL) | 38.80 ± 2.29 | 214.00 ± 48.95c | 109.30 ± 20.85d | 86.00 ± 7.57d |
| Serum AST (U/mL) | 126.40 ± 4.72 | 302.70 ± 51.72b | 211.30 ± 7.88 | 137.70 ± 21.42e |
| Serum ALP (U/mL) | 60.60 ± 1.80 | 86.20 ± 4.60b | 91.00 ± 4.16b | 88.00 ± 6.08b |
Data are expressed as the mean ± SE of the mean (n = 6-7).
a
P < 0.05.
b
P < 0.01.
c
P < 0.001 vs C.
d
P < 0.05.
e
P < 0.01.
f
P < 0.001 vs high fat diet group. ALP: Alkaline phosphatase; ALT: Alanine transaminase; AST: Aspartate transaminase; C: Control; HFD: High fat diet; HFH: High fat diet treated with 1 mL of papaya juice/100 g body weight; HFL: High fat diet treated with 0.5 mL of papaya juice/100 g body weight.