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Docking of telcagepant (magenta) and compound 1 (purple) in our pseudo (hybrid)-model of the AM2 receptor-binding pocket. The Glu74 residue from RAMP3 is indicated in green. CLR is shown in yellow and RAMP3 in cyan. Hydrogen bonds are shown as dotted lines. Compound 1 has similar spatial occupancy and interactions to telcagepant (magenta) as observed in the CGRP receptor crystal structure (PDB code 3N7R(36)).
