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Docking of compound (R)-25 in our pseudo (hybrid)-model of the AM2 receptor-binding pocket. Glu74 residues from RAMP3 are indicated in green. CLR is shown in yellow and RAMP3 in cyan. Hydrogen bonds are shown as dotted lines. The protonated amine of compound (R)-25 forms salt bridges with the carboxylate of Glu74 and the carboxylate of Asp71 (an asparagine carboxamide in RAMP3).
