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. 2021 Mar 29;2(5):100242. doi: 10.1016/j.patter.2021.100242

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

PPIs prediction for SARS-CoV-2

(A) The known and predicted bindings between the S-protein in SARS-CoV-2 and ACE2 in mammalian hosts. Host names are displayed in their abbreviation form: Hom.Sap., Homo sapiens; Mus.Mus., Mus musculus; Fel.Cat., Felis catus; Can.Lup., Canis lupus familiaris; Ovi.Ari., Ovis aries; Rat.Nor., Rattus norvegicus; Mac.Mul., Macaca mulatta; Rhi.Fer., Rhinolophus ferrumequinum; Mes.Aur., Mesocricetus auratus; Bos.Tau., Bos taurus; Ict.Tri., Ictidomys tridecemlineatus; Cam.Dro., Camelus dromedarius; Sus.Scr., Sus scrofa domesticus.

(B–D) The known and predicted interactions of M protein (B), nsp15 (C), and ORF6 (D) in SARS-CoV-2 with proteins in the human IFN signaling pathway that contribute to IFN signaling pathway suppression.