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. 2021 Mar 16;13:93. doi: 10.1007/s40820-021-00611-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 16 — a Schematic illustrations of the fabrication process for the implantable polycaprolactone/polylactic acid (PCL/PLA) MN patch. b Schematic illustrations of the implantable microneedles (MNs) with near-infrared light triggerable properties. c Schematic illustrations of the implantable MN system and its composition, containing both the drug and near-infrared light absorber. d Histological sections of rat skin after insertion of coumarin 6-loaded MNs and then exposure to a near-infrared laser for 0 and 3 min. The arrows show the diffusion of the released coumarin 6 into the skin. PVP: polyvinylpyrrolidone; PVA: polyvinyl alcohol. Reprinted from Ref. [193] with permission from Royal Society of Chemistry