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. 2021 Mar 14;9(1):9. doi: 10.3390/jdb9010009

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Phylogenetic tree of LRP4. LRP4 is conserved across species, ranging from invertebrates to humans. Despite its functional similarities, Drosophila LRP4 shares the least evolutionary history with other LRP4s. It shares 61% identity of the extracellular domain with human LRP4 but differs in the intracellular region. Evolutionary history was inferred by using the Maximum Likelihood method and Tamura-Nei model. Multiple sequence alignment was conducted using MUSCLE. Alignments and evolutionary analyses were conducted in MEGA X. Branch lengths are measured in the number of substitutions per site [91,92,93].