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. 2021 Mar 11;11:637878. doi: 10.3389/fonc.2021.637878

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Copyright © 2021 Lin, Zou, Mo, Jin, Jiang, Yu, Jiang, Yang, He and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KIF5B and CYP24A1 are overexpressed in CRC and negatively correlate with the expression of miR-1278. (A,B) The expression of KIF5B and CYP24A1 was measured in datasets of the TCGA COAD (colon adenocarcinoma) program. KIF5B and CYP24A1 were significantly upregulated in tumor samples compared to normal tissues. (C) The protein expression of KIF5B and CYP24A1 was determined by Western blotting in 42 pairs of CRC samples. (D) Compared to peritumoral tissues, KIF5B was significantly upregulated in cancer tissues. (E) Compared to peritumoral tissues, CYP24A1 was significantly upregulated in cancer tissues. (F) KIF5B or CYP24A1 expression and miR-1278 showed a negative correlation in CRC cancer tissues. Ca, cancer; Pe, peritumoral; P, patient; *P < 0.05, **P < 0.01.