Figure 3.

Inhibition of Syk by R406 attenuates activation of NF-κB and MAPK signaling pathway in PTECs. Western blot analysis with quantitative analysis on expression of (A) p-p65 and total p65 of NF-κB and (B) p-p42/p-p44 and total p42/p44 of MAPK in PTECs incubated with conditioned medium from patients with IgAN (IgAN-CM) with and without R406, and conditioned medium from healthy control subjects (control-CM). β-actin was used as loading control. ^*p < 0.05 and ^**p < 0.01 between groups as indicated.