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. 2021 Mar 15;9:647702. doi: 10.3389/fcell.2021.647702

FIGURE 3.

FIGURE 3

YTHDF1 deficiency inhibits tumor growth and metastasis in vivo. (A) Different systems were applied including GC cell lines and cell line-derived xenograft. (B) Images of the sacrificed nude mice injected with YTHDF1 deficient BGC-823 cells and its control group in mice subcutaneous tumor model (n = 5). (C) (Left) Tumors were dissected from the nude mice of each group and photographed at 36 days after transplantation. (Right) Representative histology images in mice subcutaneous tumor model (n = 5, 200×). Scale bar, 50 μm. (D,E) Tumor weight and the tumor growth curve were measured in YTHDF1 down-expressed cells and its control group. (F) (Left) Images of pulmonary metastases in mice lung metastasis model (n = 4). Black arrows: metastatic nodules. (Right) Representative histology images in mice lung metastasis tumor model (n = 4, 100×). Scale bar, 200 μm. (G) The numbers of lung metastatic nodules in YTHDF1 down-expressed cells and its control group. GC, gastric cancer. Data are shown as means ± S.D. *P < 0.05, **P < 0.01.