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. 2021 Mar 15;12:604461. doi: 10.3389/fgene.2021.604461

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Copyright © 2021 Gu, Wang, Chen, Tang, Guo, Hu, Cui, Zhang, Yu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The PPIAP22/miR-197-3p/PPIA is correlated with immune cell infiltration and chemokines in HCC. (A) Correlation of PPIA expression with immune cell infiltration in HCC analyzed using TIMER. (B) Kaplan-Meier plots for immune cell infiltration and overall survival of HCC were visualized using TIMER. (C) Correlation of PPIA expression with chemokines in HCC analyzed using TISIDB. (D) Correlation of PPIA expression with C-C motif chemokine ligand 15 (CCL15) and C-X-C motif chemokine ligand 12 (CXCL12) in HCC analyzed using TISIDB. (E) CCL15 was upregulated in tumor tissues with HCC and CXCL12 was deregulated compared with normal tissues, analyzed with GEPIA using TCGA and GTEx databases. PPIAP22, peptidylprolyl isomerase A pseudogene 22; PPIA, peptidylprolyl isomerase A; miR, microRNA; HCC, hepatocellular carcinoma; CCL15, C-C motif chemokine ligand 15; and CXCL12, C-X-C motif chemokine ligand 12. ^*p < 0.05.