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. 2021 Mar 15;11:641261. doi: 10.3389/fcimb.2021.641261

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Copyright © 2021 Geddes, Brustolini, Cavalcante, Moreira, de Castro, Guimarães, Gerber, Figueiredo, Diniz, Neto, Tanuri, Souza, Assunção-Miranda, Alves-Leon, Romão, de Souza, de Vasconcelos and de Aguiar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enriched up-regulated pathways in CHIKV, MAYV, OROV, and ZIKV infected astrocytes. Cell pathways with up-regulated genes in (A) CHIKV (18 hpi), (B) MAYV (18 hpi), (C) OROV (18 hpi), and (D) ZIKV (48 hpi) infected cells. Circus plot of Gene Set Enrichment Analysis (GSEA) of the five up-regulated most significantly enriched Reactome pathways (dark red sectors at the bottom of the circus plot) with the 50 associated DEGs. The 20 most significant up-regulated pathways are depicted. In the upper sector of the circus plot the genes were ordered by modulus of log2 Fold Change relative to uninfected cells.