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. 2021 Mar 9;11:602712. doi: 10.3389/fonc.2021.602712

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Copyright © 2021 Wang, Li, Yan, Wu, Wen, Liu, Fan and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enriched GO and KEGG pathways between proteins in the LG and rhILG. Three replicates were performed for each group. (A) Top 10 enriched GO terms using Fisher's exact test for the biological process (BP), molecular function (MF), and cellular component (CC) categories. The vertical axis represents GO terms in each category, and the numbers beside the bars are enrichment factors, which represent the significance and reliability of proteins enriched in this item. The reliability of the proteins in an item was enhanced when the value increased. The horizontal axis demonstrates the –log 10 (p-value) of each item. (B) Total level 2 GO enrichment in the BP, MF, and CC categories. The vertical axes represent numbers of differentially expressed proteins that belong to a specific GO item (left) and the ratio of proteins in the item to the total differentially expressed proteins. (C) Significantly enriched pathways between the LG and rhILG using Fisher's exact test. The horizontal axis shows the significance of each pathway in the form of –log 10 (p-value). Numbers beside the bars are enrichment factors of each enriched pathway.