Table 1.
Enrichment of proteins and signaling pathways between the LG and rhILG groups based on GO and KEGG analysis.
| Terms | Protein number | p-Value | FDR | Enrichment factor | Protein names (gene names) |
|---|---|---|---|---|---|
| GO | |||||
| (MF) Rho GTPase binding |
3 | 3.592E-04 | 0.5243 | 15.85 | Syntaxin-binding protein 6 (STXBP6); Anillin (ANLN); BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) |
| (CC) Tubulin complex |
9 | 4.535E-04 | 0.1962 | 3.87 | Dihydropyrimidinase-related protein 5 (DPYSL5); Cysteine-rich PDZ-binding protein (CRIPT); Rac GTPase-activating protein 1 (RACGAP1); Fragile X mental retardation syndrome-related protein 1 (FXR1); Protein regulator of cytokinesis 1 (PRC1); Kinesin-like protein (KIF18A); Kinesin-like protein (KIF2C); Kinesin-like protein (KIF18B); Microtubule-associated protein 1A (MAP1A) |
| (BP) Microtubule depolymerization |
3 | 2.379E-05 | 1 | 47.55 | Kinesin-like protein (KIF18A); Kinesin-like protein (KIF2C); Kinesin-like protein (KIF18B) |
| KEGG PATHWAYS | |||||
| Estrogen signaling pathway | 3 | 0.01248 | 0.4391 | 6.16 | Proto-oncogene (FOS); Keratin; type I cytoskeletal 17 (KRT17); Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) |
| Apoptosis | 3 | 0.02134 | 0.4391 | 5.04 | Proto-oncogene (FOS); Cytochrome c (CYCS); Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) |
| Amphetamine addiction | 2 | 0.01942 | 0.4391 | 9.24 | Protein fosB (FOSB); Proto-oncogene (FOS) |
| IL-17 signaling pathway | 2 | 0.02428 | 0.4926 | 8.22 | Protein fosB (FOSB); Proto-oncogene (FOS) |
| Oocyte meiosis | 3 | 0.02874 | 0.6082 | 4.50 | Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1); Cytoplasmic polyadenylation element-binding protein 4 (CPEB4); F-box only protein 5 (FBXO5) |
| Kaposi sarcoma-associated herpesvirus infection | 3 | 0.02975 | 0.4961 | 4.44 | Proto-oncogene (FOS); Cytochrome c (CYCS); Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) |
| Circadian entrainment | 2 | 0.03528 | 0.4391 | 6.72 | Proto-oncogene (FOS); Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) |
| Cholinergic synapse | 2 | 0.04350 | 0.4391 | 6.00 | Proto-oncogene (FOS); Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) |
GO, gene ontology; KEGG pathways, Kyoto encyclopedia of genes and genomes pathways; MF, molecular functions; CC, cellular components; BP, biological processes; FDR, false discovery rate. GO and KEGG pathway enrichment were analyzed by the Fisher' exact test, and p < 0.05 were considered significant.