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. 2021 Mar 9;11:637298. doi: 10.3389/fonc.2021.637298

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Copyright © 2021 Sanches, Song, Zhang, Cui, Yabasin, Ntim, Li, He, Zhang, Mao, Lu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The downregulation of KDM2B and EZH2 inhibits the migration and invasion in CRC cells. HT-29 and DLD-1 cells were treated with either shKDM2B or shEZH2. (A–G) The migration and invasion abilities of the cells were examined by scratch wound healing assay, migration, and invasion assay (Transwell assay). (A) A representative image of the wound area after the scratched wound healing assay. (B,C) The cluster bar chart of the wound area in μm at various time points. (D,F–H) Representative pictures and the cluster bar chart of migrated and invaded HT-29 and DLD-1 cells. The data was statistically significant at *p < 0.05, **p < 0.01, ***p < 0.001 as compared to control. Data are represented as mean ± SEM of three independent experiments.