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. 2021 Mar 10;8:645807. doi: 10.3389/fvets.2021.645807

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Copyright © 2021 Yang, Ding, Qian, Jiang, Chen, Zhang, Lu, Wu, Sun, Pan, Li and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression profiling of glucose metabolism-related genes in the colon of S. japonicum-infected mice. Intestinal tissues were obtained from control mice or mice infected with S. japonicum for 9 weeks. (A) The mRNA levels of glycolysis-related genes (HIF-1α, PK and PFKFB3), gluconeogenesis-related genes (PGC-1α, Phosphoenolpyruvate carboxykinase 1 and G6pc), TCA-related genes (CS, SDHA, and IDH3G) and Glucose transporter-related genes (GLUT4 and GLUT2). (B,C) The protein expression level of PKM2 and PGC-1α. Data are expressed as mean ± standard error of means (n = 4). Similar results were observed in three independent experiments. (Student's t-test: *p < 0.05, **p < 0.01, ***p < 0.001).