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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: J Biomol NMR. 2019 Jun 26;73(6-7):347–364. doi: 10.1007/s10858-019-00257-1

Fig. 1.

Fig. 1

Available TSPO structures have limitations as templates for human TSPO. A The structure of mouse TSPO (mTSPO) was determined by NMR in DPC micelles and conflicts with structural features seen in the crystal structures of TSPO from Rhodobacter sphaeroides (rsTSPO) and Bacillus cereus (bcTSPO), especially in helix III (colored blue). B Multiple sequence alignment of mammalian and bacterial TSPOs [generated with Clustal Omega (Larkin et al. 2007)]. Identical and similar residues are colored blue and gray, respectively. The sequence identity of rsTSPO and bcTSPO to hTSPO is as low as 30% and 25%, respectively