Table 1.

Comparison of animalcules and other popular microbiome analysis tools

	Biobakery	Vegan	Mothur	Microbiome	Metavizr	Microbiome helper	Qiime2	Phyloseq	animalcules
Filtering and data summary	✔		✔	✔		✔	✔	✔	✔
Interactive visualization					✔		✔		✔
Dimension reduction			✔	✔	✔	✔	✔	✔	✔
Differential abundance analysis	✔		✔	✔	✔	✔	✔	✔	✔
Diversity analysis		✔	✔	✔	✔	✔	✔	✔	✔
Support for 16S rRNA data	✔	✔	✔	✔	✔	✔	✔	✔	✔
Support for total RNA-seq data	✔	✔							✔
Biomarker identification							✔		✔
Interface and command-line						✔	✔		✔
Language/platform	Python	R	R/Web	R	R	R/Python/Perl	Python	R	R