Fig. 13.

Pathway 11 Human health: Transgenic proteins could cause specific allergic or toxicological responses in humans from dsxF transgenic bites beyond responses to non-transgenic bites. For toxicological responses, manifestation of this potential harm would depend on (i) whether the transgenic proteins are toxic to humans; (ii) whether those proteins are expressed in the saliva of transgenics at doses known to be harmful to humans. Toxicity profiles of transgenic proteins could be informed by bioinformatics analyses and inferences from toxicology studies in NTOs. For allergic responses, this potential harm is based on the hazard to an individual human from exposure to the transgenic proteins in saliva from bites of transgenic mosquitoes