Fig. 16.

Pathway 14 Human health: Potentially decreased mosquito defence response to pathogen in dsxF^CRISPRh transgenics from altered levels of endogenous RNA, protein or microbiome could lead to increased human disease. Mosquito RNA or protein in saliva, midgut or haemolymph, or contents of the microbiome, can alter defence responses to pathogens such as Plasmodium or ONNV [112–116]. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation