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. 2021 Mar 29;20:170. doi: 10.1186/s12936-021-03674-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 22 — Pathway 20 Human health: Potentially increased vector competence in dsxF^CRISPRh transgenics could increase disease transmission in humans. While increased vector competence (bc) would lead to increases in vectorial capacity, the net effect of a population suppression gene drive could ultimately reduce the impact of this potential harm by reducing the density of mosquitoes (A), including transgenic ones. Alternatively, vector competence could increase as a result of decreased densities of An. gambiae [149, 150], which would be assessed via the modelling outlined in steps two and four of the analysis plan. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation