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. 2021 Mar 15;9:647527. doi: 10.3389/fcell.2021.647527

Figure 1.

Figure 1

CCNE1 are overexpressed in TNBC and associated with poor prognosis. (A) Expression difference analysis of cyclins according to TCGA BRCA database [log2(fold change) >1, p < 0.05]. (B) Pan-cancer analysis of CCNE1 by TCGA and GTEx database. (C,D) CCNE1 expression in different TNM stages (C) or ER/PR/HER-2 status (D) in TCGA BRCA database. (E) CCNE1 expression in TNBC samples as compared with luminal-type breast cancer or normal breast samples from TCGA database. (F,G) CCNE1 expression in 30 human TNBC or 15 luminal-type breast cancer tissues and 45 adjacent normal breast tissues were detected by qRT-PCR (F) and four pairs by western blot (G). 1–4, tissue sample No.; T, TNBC tissue; N, normal breast tissue. (H) Survival curve of 3-year overall survival in 115 patients with TNBC according to the CCNE1 expression from TCGA database. (I,J) Expression of CCNE1 in breast cancer cell lines and HBL-100 were detected by qRT-PCR (I) and western blot (J). Data are presented as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.