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. 2021 Mar 15;9:647527. doi: 10.3389/fcell.2021.647527

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Copyright © 2021 Chen, Miao, Si, Qin, Zhang, Chu, Li, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of SENP3-EIF4A1/miR-195-5p/CCNE1 axis in regulating TNBC. DNA hypermethylation of miR-195-5p decreases miR-195-5p and the lncRNA SENP3-EIF4A1 functions as a sponge of miR-195-5p to promote TNBC development through increasing CCNE1 expression.