Table 5.
Assessment of the efficacy of ibrexafungerp and a comparator against both wild-type and echinocandin-resistant C. glabrata infections in a neutropenic mouse model (Lockhart et al., 2012).
| Group | Dose | Mean log10 CFU/g ± SD | |||
|---|---|---|---|---|---|
| Wild-type | P-value vs. Placebo | Echinocandin-resistant | P-value vs. Placebo | ||
|
Placebo
(Methylcellulose) |
5.58 + 1.11 | ——– | 3.99 + 1.04 | ——– | |
| Ibrexafungerp | 30 mg/kg | 3.57 ± 0.79 | <0.01 | 2.38 ± 0.66 | <0.01 |
| 40 mg/kg | 4.18 ± 0.96 | P=0.074 | 2.34 ± 0.60 | <0.01 | |
| Caspofungin | 1 mg/kg | 2.74 ± 0.76 | P<0.01 | 3.61 ± 1.22 | >0.05 |