Table 1.
Transmission of Bovine Inocula to PoPrP-Tg001 and BoPrP-Tg110 Mice
| Inocula | Survival Time, Mean (SD), d [Diseased, PrPres-Positive/Inoculated Mice, No.]a | ||
|---|---|---|---|
| PoPrP-Tg001 | BoPrP-Tg110 (1st Passage) | ||
| 1st Passage | 2nd Passage | ||
| Ca-BSE 2 | 498 (9) [2/12]b | 198 (6) [15/15]b | 308 (5) [5/5]c |
| Ca-BSE 2/Tg110 Bo6OR | 372 [1/6]d | 208 (12) [6/6]d | 265 (35) [6/6]d |
| Ca-BSE 2/Tg008 Bo5OR | 461 (100) [3/18] | ND | 331 (73) [7/7] |
| Ca-BSE-H 02.2695 | >650 [0/6] | >650 [0/6] | 328 (15) [12/12]e |
| Ca-BSE-H 02.2695/Tg110 H | >650 [0/6] | ND | 292 (12) [6/6]e |
| Ca-BSE-H 07-644 | >650 [0/6] | ND | 274 (3) [6/6]e |
| Ca-BSE-H 07-644/Tg110 H | >650 [0/6] | >650 [0/6] | 298 (10) [7/7]e |
| Ca-BSE-L 02.2528 | >650 [0/6] | >650 [0/6] | 207 (7) [6/6] |
| Ca-BSE-L 02.2528/Tg110 L | >650 [0/6] | >650 [0/6] | 198 (1) [6/6] |
| Ca-BSE-L 43 | >650 [0/6] | ND | 188 (1) [6/6] |
| Sheep-Sc Langlade/Tg110 | >650 [0/5] | ND | 321 (8) [5/5] |
| Sheep-Sc PS48/Tg110 | >650 [0/6] | ND | 197 (1) [5/5] |
| Sheep-Sc198-9/Tg110 | >650 [0/5] | ND | 165 (7) [7/7] |
| Sheep-ScPS21/Tg110 | >650 [0/6] | ND | 187 (2) [5/5] |
| Sheep-Sc pool pre-75 cattle P75-7 | >650 [0/6]f | >650 [0/6]f | 203 (5) [6/6]f |
| Sheep-Sc pool post-90 cattle P90-1 | >650 [0/6]f | >650 [0/6]f | 173 (3) [6/6]f |
Abbreviations: BoPrP, bovine prion protein (PrP).BSE, bovine spongiform encephalopathy; ND, not done.; PoPrP, porcine PrP; PrPres, protease-resistant PrP.
aThe mean survival time is indicated for all mice scored positive for PrPres.
bPublished elsewhere [18].
cPublished elsewhere [17].
dPublished elsewhere [29].
ePublished elsewhere [5].
fPublished elsewhere [30].