Table 2.
Transmission of Sheep and Goat Inocula to PoPrP-Tg001 and Ovine Transgenic Mice
| Inocula | Survival Time, Mean (SD), d [Diseased, PrPres-Positive/Inoculated Mice, No.]a | ||
|---|---|---|---|
| PoPrP-Tg001 | Ovine PrP-Tg Miceb (1st Passage) | ||
| 1st Passage | 2nd Passage | ||
| Sheep-Sc pool pre-75 | >650 [0/6] | >650 [0/6] | 69 (1) [6/6]c (Tg338) |
| Sheep-Sc pool post-90 | >650 [0/6] | >650 [0/6] | 480 (19) [6/6]c (Tg338) |
| Sheep-Sc PS09 | >650 [0/6] | >650 [0/5] | 431 (18) [6/6] (Tg338) |
| Sheep-Sc PS21 | >650 [0/6] | >650 [0/6] | 182 (17) [6/6] (Tg338) |
| Sheep-Sc PS42 | >650 [0/7] | >650 [0/5] | 67 (7) [6/6] (Tg338) |
| Sheep-Sc198-9 | >650 [0/5] | ND | 629 (27) [5/5] |
| Sheep-ScO100 | >650 [0/6] | >650 [0/5] | 364 (61) [12/12]d (TgOvPrP4) |
| Sheep-ScO104 | >650 [0/5] | >650 [0/5] | 248 (50) [10/10]d (TgOvPrP4) |
| Goat-Sc S2 | >650 [0/6] | >650 [0/5] | 449 (62) [9/9]e |
| Goat-F10 | >650 [0/5] | ND | 465 (17) [7/7]e |
| Goat-Sc Goujon | >650 [0/6] | >650 [0/5] | 253 (7) [5/5] |
| Goat-AtSc I15 | >650 [0/6] | ND | 552 (78) [6/6]f |
| Sheep-AtSc Engavagen | >650 [0/10] | >650 [0/5] | 227 (15) [11/11] (Tg338) |
| Sheep-AtSc Leknes | >650 [0/9] | ND | ND |
| Sheep-AtSc Kjerringøy | >650 [0/5] | >650 [0/5] | 285 (43) [6/6] (Tg338) |
| Sheep-AtSc Suldalsosen | >650 [0/6] | >650 [0/5] | ND |
| Sheep-AtSc Tennevoll | >650 [0/5] | ND | 245 (15) (Tg338) |
| Sheep-AtSc Vinje | >650 [0/5] | ND | ND |
| Sheep-AtSc 152 | 300–600 [2/12]g | 162 (13) [9/9]g | 418 (6) [6/6] |
| Sheep-AtSc 152 | >650 [0/9] | ND | ND |
| Sheep-AtSc 152/Tg338 | >650 [0/6] | >650 [0/5] | ND |
| BSE in sheep ARQ/ARQ | 458 (11) [15/15]g | 162 (4) [13/13]g | 485 (62) [7/7]e |
| BSE in sheep ARR/ARR | 471 (58) [9/9] | 185 (5) [5/5] | 358 (20) [6/6] |
| BSE in TgOV ARQ | 389 (37) [5/5] | ND | ND |
| BSE in TgOV ARR | 417 (18) [5/5] | 183 (14) [6/6] | ND |
| Experimental BSE in goat | 459 (27) [5/5] | 176 (5) [5/5] | 497 (31) [5/5]e |
| BSE in goat CH636 | 505 (60) [7/7] | 182 (9) [7/7] | ND |
Abbreviations: BSE, bovine spongiform encephalopathy; ND, not done; PoPrP, porcine prion protein; PrPres, protease-resistant prion protein.
aThe mean survival time is indicated for all mice scored positive for PrPres.
bData from ovine PrP-Tg501 mice [25] except for those indicated as either Tg338 [10] or TgOvPrP4 [31].
cPublished elsewhere [30].
dPublished elsewhere [31].
ePublished elsewhere [25].
fPublished elsewhere [32].
gPublished elsewhere [18].