Table 3.
Transmission of Mouse and Hamster Inocula in PoPrP-Tg001, Tga20 transgenic Mice or Hamsters
| Inocula | Survival Time, Mean (SD), d [Diseased, PrPres-Positive/Inoculated Mice, No.]a | |||
|---|---|---|---|---|
| PoPrP-Tg001 | Tga20 (1st Passage) | Hamsters (1st Passage) | ||
| 1st Passage | 2nd Passage | |||
| BSE in Tga20 | 506 [1/6]b | ND | 154 (21) [5/5] | ND |
| BSE in wt mouse | 650 [1/6]b | 201 (12b) [6/6] | 158 (39) [5/5] | ND |
| 22L | >650 [0/6] | >650 [0/6] | 112 (13) [4/4] | ND |
| RML | >650 [0/6]b | >650 [0/6]b | 75 (7) [5/5] | ND |
| 263K | >650 [0/7] | >650 [0/5] | ND | 87 (3) [5/5] |
Abbreviations: BSE, bovine spongiform encephalopathy; ND, not done; PoPrP, porcine prion protein; PrPres, protease-resistant prion protein; wt, wild-type.
aThe mean survival time is indicated for all mice scored positive for PrPres.
bPublished elsewhere [29].