Table 4.
Transmission of Human Inocula in PoPrP-Tg001 and HuPrP-Tg340 Transgenic Mice
| Inocula | Survival Time, Mean (SD), d [Diseased, PrPres-Positive/Inoculated Mice, No.]a | ||
|---|---|---|---|
| PoPrP-Tg001 | HuPrP-Tg340 (1st Passage) | ||
| 1st Passage | 2nd Passage | ||
| sCJD 129 M/M T1 NHBX0/0001 | >650 [0/6]b | >650 [0/6]b | 214 (6) [5/5]b |
| sCJD 129 M/M T1 0.08.02523_001 | >650 [0/6] | ND | 187 (11) [6/6] |
| sCJD 129 V/V T2 0.08.02497_001 | >650 [0/5] | ND | 522 (36) [6/6] |
| vCJD 129 M/M NHBY0/0014 | 556 (81) [6/6]b | 212 (6) [6/6]b | 626 (29) [6/6]b |
| vCJD 129 M/M BC1458 | 530 (48) [6/6] | 197 (9) [5/5] | 545 (146) [5/5]c |
| BSE in HuPrP-Tg340 | 486 (31) [5/6] | ND | 614 (87) [6/6]c |
Abbreviations: BSE, bovine spongiform encephalopathy; HuPrP, human prion protein (PrP); ND, not done; PoPrP, porcine PrP; PrPres, protease-resistant PrP; sCJD, sporadic Creutzfeldt-Jakob disease; vCJD, variant Creutzfeldt-Jakob disease.
aThe mean survival time is indicated for all mice scored positive for PrPres.
bPublished elsewhere [29].
cPublished elsewhere [33].