FIGURE 3.

Pyr1 treatment alleviates behavioral defects of MAP6 KO mice (A) Effect of Pyr1 on social behavior. Social interaction was assayed by measuring the time a MAP6 KO resident male spent sniffing an intruder (78.8 ± 6.2 and 102.0 ± 9.6 for untreated and Pyr1-treated mice, respectively). Sniffing behavior was analyzed over a 5 min period. Values correspond to mean ± SEM. Mann-Whitney test, p = 0.046. n = 11 for untreated mice and n = 7 for Pyr1-treated mice (B) Effect of Pyr1 on depressive/anxiety status. Novelty Suppressed Feeding (NSF) test was used to measure the latency to eat (509.3 ± 73.6 and 266.4 ± 39.7 for untreated and Pyr1-treated mice, respectively). Values correspond to mean ± SEM. Mann-Whitney test, p value is indicated. n = 7 for untreated and Pyr1-treated mice.