Table 1.

Drugs with an increased likelihood of inducing thyroid dysfunction.

Inhibit thyroidhormone production	Alter extra-thyroidal metabolismof thyroid hormone	Alter T4/T3 bindingto plasma proteins	Induction of thyroiditis	Affection of TSH secretion	Impairing absorption of oral T4
Antithyroid drugs	Propylthiouracil	Estrogen	Amiodarone	Lithium	Aluminum hydroxide
Amiodarone	Glucocorticoids	Heroin	Interleukin-2	Dopamine Receptor Blockers	Ferrous Sulfate
Lithium	Propranolol	Methadone	Interferon-α	L-Dopa Inhibitors	Cholestyramine
Iodide (large doses)	Amiodarone	Clofibrate	Interferon-β	Cimetidine	Calcium Carbonate
Iodine-containing contrast media	Iodine-containing contrast media	5-Fluorouracil	γ-Interferon	Clomifene	Calcium Citrate
	Carbamazepine	Perphenazine	Sunitinib	Thyroid Hormone	Calcium Acetate
	Barbiturates	Glucocorticoids	Monoclonal antibody therapy (the check point inhibitors: Nivulomab, Pembrolizumab, Ipilimimab)	Dopamine	Iron Sulfate
	Rifampicin	Androgens		L-Dopa	Colestipol
	Phenytoin	L-Asparaginase		Glucocorticoids	Sucralfate
	Sertralin	Nicotinic Acid		Growth Hormone	Soya preparations
		Furosemid		Somatostatin	Kayexalate
Other		Salicylates		Octreotide	Ciprofloxacin
Thalidomide		Phenytoin			Sevelamer
Lenalidomide		Fenclofenac			Proton pump inhibitors
Chemotherapy for sarcoma		Heparin