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. 2021 Mar 9;11:625109. doi: 10.3389/fonc.2021.625109

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Copyright © 2021 Wang, Wu, Song, Chen, Hu, Xu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between plasma exosome-derived SENP1 levels and tumor characteristics. (A) No significant differences were observed between male and female patients (P = 0.104). (B) No significant differences were found between patients aged <20 and >20 years (P = 0.133). (C) Plasma exosome-derived SENP1 levels of patients with osteosarcoma with tumor size >10 cm were significantly higher than those in patients with tumor size <10 cm (P < 0.001). (D) Plasma exosome-derived SENP1 levels of patients with osteosarcoma located in distal extremity were significantly higher than those in patients with osteosarcoma located in proximal extremity (P = 0.008). (E) Plasma exosome-derived SENP1 levels of patients with osteosarcoma with necrosis rate >90% were significantly higher than those in patients with necrosis rate <90% (P < 0.001). (F) Plasma exosome-derived SENP1 levels of patients with osteosarcoma with pulmonary metastasis were significantly higher than those in patients without pulmonary metastasis (P < 0.001). (G) Plasma exosome-derived SENP1 levels of patients with osteosarcoma in surgical stag III;+IV were significantly higher than those in patients with osteosarcoma in surgical stage I+II (P < 0.001).