Table 2.
The prognostic value of plasma exosome-derived SENP1 levels in osteosarcoma.
| Variable | (n = 146) |
|---|---|
| AUROC (1-year DFS) | 0.90 (0.83–0.98) |
| Cutoff value (95% CI) | 322.17 |
| Sensitivity, % | 87.5 (47.3–99.7) |
| Specificity, % | 89.1 (82.7–93.8) |
| Positive predictive value, % | 31.8 (13.9–54.9) |
| Negative predictive value, % | 99.2 (95.6–100.0) |
| Positive likelihood ratio | 8.05 (4.7–13.9) |
| Negative likelihood ratio | 0.14 (0.02–0.9) |
| AUROC (3-year DFS) | 0.96 (0.94–0.99) |
| Cutoff value (95% CI) | 226.25 |
| Sensitivity, % | 91.8 (83.0–96.9) |
| Specificity, % | 89.0 (79.5–95.1) |
| Positive predictive value, % | 89.3 (80.1–95.3) |
| Negative predictive value, % | 91.5 (82.5–96.8) |
| Positive likelihood ratio | 8.38 (4.3–16.2) |
| Negative likelihood ratio | 0.092 (0.04–0.2) |
| AUROC (1-year OS) | 0.90 (0.82–0.99) |
| Cutoff value (95% CI) | 327.81 |
| Sensitivity, % | 85.7 (42.1–99.6) |
| Specificity, % | 90.6 (84.5–94.9) |
| Positive predictive value, % | 31.6 (12.6–56.6) |
| Negative predictive value, % | 99.2 (95.7–100.0) |
| Positive likelihood ratio | 9.16 (5.0–16.7) |
| Negative likelihood ratio | 0.16 (0.03–1.0) |
| AUROC (3-year OS) | 0.96 (0.93-0.98) |
| Cutoff value (95% CI) | 249.33 |
| Sensitivity, % | 83.3 (72.1–91.4) |
| Specificity, % | 95.0 (87.7–98.6) |
| Positive predictive value, % | 93.2 (83.5–98.1) |
| Negative predictive value, % | 87.4 (78.5–93.5) |
| Positive likelihood ratio | 16.67 (6.4–43.6) |
| Negative likelihood ratio | 0.18 (0.1–0.3) |
SENP1, sentrin sumo-specific protease 1; AUROC, area under the receiver operating characteristic curve; DFS, disease-free survival; OS, overall survival.