Table 5.

AD-DMPs resulting from cross-region analysis.

Intersection	Probe	Chr	MAPINFO	Relation	Gene	Effect size direction	Smith et al.	Cited in previous studies in relation to AD
TC ∩ ERC	cg00851830	14	100201016	N_Shelf		+
	cg03169557	16	89598950		SPG7	+	X	Retinal nerve fiber layer loss; AD DMP (Wiethoff et al., 2012; Li Q. S. et al., 2020)
	cg03183618	2	134964228			+
	cg04658038	17	64800166		PRKCA	+		Synaptic degeneration (Wang et al., 2010; Alfonso et al., 2016; Maphis et al., 2017)
	cg05066959 cg11823178	8	41519308 41519399		ANK1, MIR486	+	X	Epigenetic changes in AD; involved in memory loss (De Jager et al., 2014; Lord and Cruchaga, 2014; Lunnon et al., 2014; Chi et al., 2016; Mastroeni et al., 2017; Gasparoni et al., 2018; Higham et al., 2019; Blanco-Luquin et al., 2020; Li Q. S. et al., 2020)
	cg05397697	14	90042217		PRO1768, FOXN3	+
	cg05417607	17	1373605	N_Shore	MYO1C	+	X
	cg05810363,	17	74475270	Island	RHBDF2	+	X	Epigenetic changes in AD (De Jager et al., 2014; Lord and Cruchaga, 2014; Zou et al., 2019; Li Q. S. et al., 2020)
	cg12163800,		74475355
	cg12309456		74475402
	cg06653632	12	129281444	S_Shore	SLC15A4	+
	cg06753513	17	3977385		ZZEF1	+
	cg07012687	17	80195180	Island	SLC16A3	+
	cg07571519	10	73472315		C10orf105, CDH23	+		Expression and epigenetic changes in AD (De Jager et al., 2014; Lord and Cruchaga, 2014; Humphries et al., 2015; Hu et al., 2018)
	cg09123026	17	74480528		RHBDF2	+		Epigenetic changes in AD (De Jager et al., 2014; Lord and Cruchaga, 2014; Zou et al., 2019; Li Q. S. et al., 2020)
	cg13851211	16	50321678		ADCY7	+
	cg14025831	20	3873404	S_Shelf	PANK2	+
	cg14761246	3	182968758	N_Shelf	MCF2L2	+
	cg14798745	4	184315677	N_Shelf		+
	cg18102633	19	17487776	N_Shore	PLVAP	+
	cg18456331	10	77188318	N_Shelf		+
	cg18923906	10	82225771		TSPAN14	+
	cg20148994	7	130125585	N_Shore	MEST	+
	cg21221455	15	63342288	S_Shore	TPM1	+
	cg22090150	17	4098227		ANKFY1	+	X
	cg22656126	17	1637206	Island	WDR81	+
	cg25018458	17	980014	N_Shore	ABR	+	X	Hearing loss (Irimajiri et al., 2005; Oh et al., 2010; O'Leary et al., 2017; Hacohen-Kleiman et al., 2019; Liu et al., 2020)
	cg27630153	16	88845038	Island	FAM38A	+
FC ∩ TC ∩ ERC	cg12163800	17	74475355	Island	RHBDF2	+	X	Epigenetic changes in AD (De Jager et al., 2014; Lord and Cruchaga, 2014; Zou et al., 2019; Li Q. S. et al., 2020)
FC ∩ TC	cg01463828	8	22446721		PDLIM2	+	X
	cg02317313	12	122	Island	LOC338799	+	X
	cg04874795	16	86477638			-	X
	cg07061298	7	27153847	N_Shore	HOXA3	+	X	Epigenetic changes in AD (Gasparoni et al., 2018; Hernández et al., 2018; Smith et al., 2018; Li Q. S. et al., 2020)
	cg12163800	17	74475355	Island	RHBDF2	+	X	Epigenetic changes in AD (De Jager et al., 2014; Lord and Cruchaga, 2014; Zou et al., 2019; Li Q. S. et al., 2020)
	cg22962123	7	27153605	Island	HOXA3	+	X
	cg26022064	7	98739782	N_Shore	SMURF1	+	X	Neural necroptosis and Hirano bodies (Makioka et al., 2014; Shao et al., 2018)
	cg26199857	12	54764265	Island	ZNF385A	+
FC ∩ ERC	cg12163800	17	74475355	Island	RHBDF2	+	X
	cg13076843		74475294