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. 2021 Mar 16;13:92. doi: 10.1007/s40820-021-00622-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The PFD inserts into the hydrophobic chamber of β-CD, and the GEM was encapsulated in the liposome. If the LRC-GEM-PFD is cleaved by MMP-2, the PFD part will regulate the PSCs, and the GEM containing liposome will recognize and kill the PTCs. b Synthesis of pep-CD, DSPE-PEG(3400)-pep-CD, and DSPE-PEG(3400)-RGD. c The immunofluorescence staining of collagen I and TGF-β. Blue: HOECHST, green: FITC-labeled collagen I or TGF-β. The scale bar: 50 μm. d The Western blot analysis of the collagen I and TGF-β in the conditioned medium of PSCs. e Penetration of Rhd into pancreatic tumor (Panc-1 and PSCs coimplanted) tissues after intravenous injection of different PFD formulations. Red: Rhd. The scale bar is 100 μm. f Tumor growth curves of PSCs/Panc-1 pancreatic tumors in mice treated by different GEM formulations. GEM dose: 20 mg/kg. Data were presented as mean ± standard deviation *p < 0.05, **p < 0.01 vs control.

Reproduced with permission from Ref. [179]