Table 2.
MHC Amino acid residues interacting with CD4.
| Alpha gene | Position | |||
|---|---|---|---|---|
| 88 | 90 | 176 | ||
| DR1/15 | DRA*0101 | E | T | K |
| DQ8 | DQA1*0301 | E | T | K |
| DQ2 | DQA1*0501 | E | T | K |
| DP4 | DPA1*0103 | E | T | K |
| I-Ag7 | I-Ag7 alpha | Q | T | K |
| Beta gene | Position | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 104 | 114 | 116 | 142 | 143 | 144 | 145 | 148 | 158 | 160 | 162 | ||
| DR1 | DRB1*0101 | S | L | V | V | V | S | T | I | L | M | E |
| DR15 | DRB1*1501 | S | L | V | M | V | S | T | I | L | M | E |
| DQ8 | DQB1*0302 | S | L | V | V | V | S | T | I | L | M | E |
| DQ2 | DQB1*0201 | S | L | V | V | V | S | T | I | L | M | E |
| DP4 | DPB1*0401 | S | L | V | V | V | S | T | I | L | M | E |
| I-Ag7 | I-Ag7 beta | S | T | V | V | S | S | T | I | L | M | E |
The previous study by Mariuzza and his colleagues determined amino acid residues in HLA-DR1 that interact with the mutated human CD4 having Q40Y and T45W (Wang et al., 2011). The table shows amino acids of other MHC class II alleles in these positions.