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. Author manuscript; available in PMC: 2021 Oct 28.
Published in final edited form as: Chem Rev. 2020 Sep 24;120(20):11479–11615. doi: 10.1021/acs.chemrev.0c00523

Figure 133.

Figure 133.

(a) Strategy for the synthesis of diverse peptide catalysts scaffolds via a four-component Ugi reaction. (b) Asymmetric conjugate addition of aldehyde 7.47 into nitroolefin 7.2 catalyzed by peptide 7.49.330 (c) Diversity oriented approach pursued by Paixao and co-workers to develop catalysts for asymmetric conjugate addition reactions and a comparison of the number of low energy conformations of peptides 7.50 and 7.51. Reproduced in part from with permission from ref. 331. Copyright 2013 American Chemical Society.