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. Author manuscript; available in PMC: 2021 Oct 28.
Published in final edited form as: Chem Rev. 2020 Sep 24;120(20):11479–11615. doi: 10.1021/acs.chemrev.0c00523

Figure 164.

Figure 164.

Peptide optimization for the VCP ring-opening/cycloaddition cascade reaction. Scaffold 9.6 led to significant improvements in enantioselectivity compared to the other archetypal peptides 9.4 and 9.5.395