Fig. 2.

Afferent arteriole responses to changes in renal perfusion pressure (RPP) and to P2X1 receptor activation in hypertensive rats. (A) Renal autoregulation was assessed by afferent arteriole responses to alterations in RPP in control (squares), Ang II-infused hypertensive rats alone (60 ng/min, circles) and treated with mycophenolate mofetil (Ang II+MMF, 30 mg/kg.day, triangles). (B) Afferent arteriole autoregulatory responses assessed in rats with uninephrectomy (UNx, squares), DOCA-salt hypertension (circles, a low-renin/low-Ang II model) and DOCA-salt hypertension with pentosan polysulphate treatment (DOCS-salt+PPS, 100 mg/kg. day, triangles). (C) Afferent arteriole responses to increasing concentrations of β, γ-methylene ATP (P2X1 and P2X3 receptor agonist) in control (squares), Ang II-infused alone (circles) and Ang II+MMF (triangles) rats. (D) Afferent arteriole responses to increasing concentrations of β, γ-methylene ATP in UNx (squares), DOCA-salt alone (circles) and DOCA-salt+PPS (triangles) rats. Both hypertensive models exhibit impaired renal autoregulation, indicated by the blunted pressure-dependent afferent arteriole vasoconstriction and also associated with reduced β, γ-methylene ATP reactivity. Anti-inflammatory treatment with MMF or PPS preserved renal autoregulation and vasoconstriction to β, γ-methylene ATP in hypertensive rats without changes in systolic blood pressure (Guan et al. 2013, 2016). Data are normalized as a percent of the control diameter at 100 mm Hg. Values are expressed as mean ± SEM. * P<0.05 vs. control diameter in the same group; ^† P<0.05 vs. control or UNx at the same RPP; ^# P<0.05 vs. Ang II+MMF or DOCA-salt+PPS at the same RPP.