Table 2.
GO analysis of the 144 differentially expressed genes.
| Category | Term | Count | P value | Benjamini | FDR | Genes |
|---|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO: 0030198 ~extracellular matrix organization | 21 | 5.81E-17 | 1.15E-13 | 1.78E-13 | COL4A2, COL4A1, OLFML2B, COL3A1, FBN1, COL2A1, SPARC, NID2, COL5A2, COL5A1, BGN, COL6A3, COL1A2, MFAP2, VCAN, COL1A1, THBS1, COL11A1, SPP1, FN1, COL10A1 |
| GOTERM_MF_DIRECT | GO: 0005201 ~extracellular matrix structural constituent | 13 | 9.89E-14 | 3.07E-11 | 1.33E-10 | COL4A2, BGN, COL4A1, COL3A1, FBN1, COL1A2, COL2A1, VCAN, COL1A1, MUC5AC, COL5A2, COL11A1, COL5A1 |
| GOTERM_CC_DIRECT | GO: 0005576 ~extracellular region | 42 | 4.25E-13 | 7.69E-11 | 5.24E-10 | GC, CHIA, IGFBP7, COL3A1, JCHAIN, APOC1, CXCL8, COL2A1, TIMP1, AZGP1, APOE, COL6A3, CPA2, LTF, PDGFD, THBS1, COL11A1, THBS2, SPP1, COL10A1, FN1, ADAM28, COL4A2, COL4A1, OLFML2B, FBN1, GIF, NID2, SPARC, COL5A2, COL5A1, INHBA, BGN, SFRP4, CEMIP, COL1A2, VCAN, MFAP2, COL1A1, CTSB, MUC5AC, LIPF |
| GOTERM_CC_DIRECT | GO: 0031012 ~extracellular matrix | 20 | 5.14E-13 | 4.65E-11 | 6.33E-10 | ASPN, COL4A2, COL4A1, IGFBP7, COL3A1, FBN1, COL2A1, NID2, COL5A2, COL5A1, BGN, APOE, COL6A3, COL1A2, VCAN, COL1A1, THBS1, THBS2, MYOC, FN1 |
| GOTERM_CC_DIRECT | GO: 0005615 ~extracellular space | 38 | 8.88E-13 | 5.36E-11 | 1.10E-09 | GC, CHIA, PGC, IGFBP7, COL3A1, JCHAIN, CXCL8, COL2A1, SERPINH1, ALDH3A1, TIMP1, AZGP1, APOE, SOSTDC1, FAP, COL6A3, CPA2, LTF, PDGFD, THBS1, MYOC, SPP1, FN1, ATP4A, FBN1, GIF, CST1, SPARC, CHGA, SFRP4, SULF1, COL1A2, VCAN, COL1A1, CTSB, MUC5AC, CA2, GKN1 |
| GOTERM_BP_DIRECT | GO: 0030574 ~collagen catabolic process | 12 | 2.42E-12 | 1.26E-09 | 3.85E-09 | COL4A2, COL4A1, COL3A1, COL6A3, COL1A2, COL2A1, COL1A1, CTSB, COL11A1, COL5A2, COL5A1, COL10A1 |
| GOTERM_CC_DIRECT | GO: 0070062 ~extracellular exosome | 51 | 3.44E-10 | 1.56E-08 | 4.24E-07 | RARRES1, PGC, IGFBP7, KIAA1324, AZGP1, APOE, LTF, AKR7A3, PDGFD, AKR1C1, ALDH6A1, FBP2, METTL7A, THY1, BGN, AKR1B10, COL1A2, CTSB, CA2, GC, GPRC5C, JCHAIN, APOC1, SERPINH1, PBLD, TIMP1, ALDH1A1, CSE1L, FOLR1, COL6A3, SULT1C2, NEDD4L, THBS1, MYOC, SPP1, FN1, MEST, GSTA1, TMPRSS2, RNASE1, COL4A2, S100P, FBN1, S100A10, NID2, ADGRG2, COL5A1, MUC5AC, FCGBP, HPGD, CDH11 |
| GOTERM_CC_DIRECT | GO: 0005581 ~collagen trimer | 11 | 1.32E-09 | 4.79E-08 | 1.63E-06 | COL3A1, COL6A3, COL1A2, COL2A1, COL1A1, COL11A1, SERPINH1, COL5A2, COL5A1, COL10A1, TIMP1 |
| GOTERM_CC_DIRECT | GO: 0005788 ~endoplasmic reticulum lumen | 14 | 1.55E-09 | 4.68E-08 | 1.91E-06 | COL4A2, COL4A1, COL3A1, COL6A3, COL1A2, COL2A1, COL1A1, PDGFD, THBS1, SERPINH1, COL5A2, COL11A1, COL5A1, COL10A1 |
| GOTERM_BP_DIRECT | GO: 0071294~cellular response to zinc ion | 7 | 5.25E-09 | 1.82E-06 | 8.34E-06 | MT1M, MT2A, MT1E, MT1H, MT1X, MT1G, MT1F |
| GOTERM_BP_DIRECT | GO: 0045926~negative regulation of growth | 7 | 5.25E-09 | 1.82E-06 | 8.34E-06 | MT1M, MT2A, MT1E, MT1H, MT1X, MT1G, MT1F |
| GOTERM_CC_DIRECT | GO: 0005578 ~proteinaceous extracellular matrix | 15 | 1.01E-08 | 2.62E-07 | 1.25E-05 | ASPN, OLFML2B, FBN1, SPARC, COL5A2, COL5A1, TIMP1, BGN, COL6A3, COL1A2, VCAN, COL11A1, MYOC, FN1, COL10A1 |
| GOTERM_MF_DIRECT | GO: 0048407 ~platelet-derived growth factor binding | 6 | 1.07E-08 | 1.66E-06 | 1.44E-05 | COL4A1, COL3A1, COL1A2, COL2A1, COL1A1, COL5A1 |
| GOTERM_BP_DIRECT | GO: 0030199~collagen fibril organization | 8 | 1.97E-08 | 5.12E-06 | 3.13E-05 | COL3A1, COL1A2, COL2A1, COL1A1, COL11A1, SERPINH1, COL5A2, COL5A1 |
| GOTERM_MF_DIRECT | GO: 0050840 ~extracellular matrix binding | 6 | 1.39E-06 | 1.44E-04 | 0.001872262 | BGN, OLFML2B, SPARC, THBS1, COL11A1, SPP1 |
| GOTERM_CC_DIRECT | GO: 0005604 ~basement membrane | 8 | 1.76E-06 | 3.99E-05 | 0.002172174 | COL4A1, FBN1, COL2A1, NID2, SPARC, THBS2, COL5A1, TIMP1 |
| GOTERM_BP_DIRECT | GO: 0007155 ~cell adhesion | 16 | 3.26E-06 | 6.77E-04 | 0.005182285 | ATP4B, IGFBP7, NID2, COL5A1, THY1, AZGP1, FAP, COL6A3, VCAN, COL1A1, THBS1, GPNMB, THBS2, SPP1, FN1, CDH11 |
| GOTERM_BP_DIRECT | GO: 0071276~cellular response to cadmium ion | 5 | 8.02E-06 | 0.001386589 | 0.012731623 | MT1E, MT1H, MT1X, MT1G, MT1F |
| GOTERM_BP_DIRECT | GO: 0007586~digestion | 7 | 9.91E-06 | 0.001467951 | 0.015725541 | CHIA, CCKBR, PGC, AKR1B10, CAPN9, GKN1, AKR1C1 |
| GOTERM_BP_DIRECT | GO: 0001501~skeletal system development | 9 | 1.26E-05 | 0.001632159 | 0.019983654 | COL3A1, FBN1, COL1A2, COL2A1, VCAN, COL1A1, COL5A2, COL10A1, CDH11 |
| GOTERM_MF_DIRECT | GO: 0005178 ~integrin binding | 8 | 1.58E-05 | 0.001223983 | 0.021220906 | FAP, COL3A1, FBN1, THBS1, GPNMB, COL5A1, FN1, THY1 |