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. 2021 Jan 7;105(3-4):169–180. doi: 10.1159/000510407

Table 4.

Recommended examinations for primary staging

Test Patients
Physical examination All patients

Ultrasonography of the testes All patients

Serum tumour markers All patients
 AFP
 β-hCG
 LDH

Chest/abdominal/pelvic CT All patients

Cranial MRI Symptomatic patients and patients in the IGCCCG poor prognosis group, or patients with multiple pulmonary metastases and/or high β-hCG values (>5,000 IU/L)

Further diagnostics Patients with unfinished family planning, active or postponed desire for offspring as well as for ruling out/detecting hypogonadism
 Fertility tests
 Sperm analysis/cryopreservation
 Testosterone
 LH
 FSH

AFP, α-fetoprotein; hCG, human chorionic gonadotropin; LDH, lactate dehydrogenase; CT, computed tomography; IGCCCG, International Germ Cell Cancer Collaboration Group; LH, luteinizing hormone; FSH, follicle-stimulating hormone. We recommend advising all patients on the cryopreservation of sperm preferably before the primary surgical intervention and, if necessary, arrange consultation with an andrologist or a fertility centre.