Table 2.
Top 5 genes and biological pathways associated to drug response prediction-based feature importance in both drug and patient spaces
| Drug space | Patient space | |
|---|---|---|
| Genes | HSP90AA1 | KRT19 |
| PIK3CA | KRT8 | |
| EGFR | KRT18 | |
| PTEN | CLDN4 | |
| PRKACA | AGR2 | |
| Pathways | Signal transduction | Extracellular matrix organization |
| Signaling by GPCR | Transport of small molecules | |
| GPCR downstream signaling | Degradation of the extracellular matrix | |
| Metabolism | Signal transduction | |
| G alpha (i) signaling events | Response to elevated platelet cytosolic Ca2+ |