Figure 4.

Adverse events in the CANVAS Program participants stratified by baseline use of any diuretic. CANVAS indicates Canagliflozin Cardiovascular Assessment Study; CI, confidence interval. *The annualized event rates are reported with data from CANVAS alone through 7 January 2014, because after this time, only serious adverse events or adverse events leading to discontinuation were collected. In CANVAS‐R, only serious adverse events or adverse events leading to discontinuation were collected. Owing to the differences between the two trials in methods of collection of the data, an integrated analysis of these adverse events is not possible. ^§Data collected in CANVAS and CANVAS‐R.