Table 1.

Anatomo‐pathological, echocardiographic data

Characteristic	Ctrl (n = 9)	Ctrl + Meto (n = 6)	Dox + Trast (n = 11)	Dox + Trast + Meto (n = 8)
Anatomical parameters
Body weight (g)	27 ± 0.8	27 ± 1.0	24 ± 0.5***	19 ± 0.9 $$$
Heart weight (mg)	119 ± 3.9	126 ± 5.5	105 ± 2.7*	86 ± 4.2 $$$
Heart weight/Tibia length (mg/mm)	5.8 ± 0.2	6.5 ± 0.3	5.3 ± 0.2	4.6 ± 0.2 $$$
Heart weight/Body weight	4.2 ± 0.07	4.6 ± 0.08	4.5 ± 0.09	4.5 ± 0.11
End diastolic left ventricular diameter (mm)	3.3 ± 0.06	3.6 ± 0.06	3.4 ± 0.08	3.5 ± 0.09
Echocardiographic data
LV mass (mg/mm2)	80 ± 5.8	100 ± 3.0	68 ± 3.9**	76 ± 4.3 $$
Shortening fraction (%)	55 ± 0.9	50 ± 1.8	40 ± 1.3***	41 ± 2.0 $
LVEF (%)	87 ± 0.8	81 ± 2.1	74 ± 2.7***	71 ± 2.7 $
Heart rate (beats per min)	614 ± 15	571 ± 37	598 ± 15	322 ± 29 $$$
Intracardiac AMPc (pmol/mg proteins)	7.7 ± 0.7	2.2 ± 0.3	56 ± 5.3***	20 ± 0.5 $$

LV, Left ventricle; LVEF, left ventricular ejection fraction.

^*Ctrl vs. Dox + Trast P < 0.05,

^** P < 0.01,

^*** P < 0.001 using two‐way ANOVA test followed by Bonferroni post hoc test.

^$Ctrl + Meto vs. Dox + Trast + Meto P < 0.05,

^$$ P < 0.01,

^$$$ P < 0.001 using two‐way ANOVA test followed by Bonferroni post hoc test.