Table 3.
LV performance and ventriculo–arterial coupling at baseline and after adding mineralocorticoid receptor antagonist in NIDCM patients
| Baseline | Follow‐up | Change | P | |
|---|---|---|---|---|
| Heart rate (bpm) | 67 (58, 71) | 72 (65, 76) | 5 (3, 12) | 0.021 |
| Systolic BP (mmHg) | 121 (115, 125) | 122 (112, 134) | 2 (−5, 11) | 0.46 |
| Diastolic BP (mmHg) | 67 (63, 73) | 72 (65, 79) | 4 (−1, 10) | 0.059 |
| MAP (mmHg) | 84 (80, 90) | 89 (81, 97) | 1 (−1, 10) | 0.21 |
| LVEF (%) | 24 (17, 27) | 47 (42, 52) | 22 (15, 34) | 0.002 |
| LVEDVI (mL/m2) | 82 (74, 91) | 74 (59, 82) | −8 (−14, −5) | 0.003 |
| LVESVI (mL/m2) | 63 (56, 78) | 36 (31, 46) | −24 (−32, −19) | 0.002 |
| LVSVI (mL/m2) | 19 (14, 21) | 36 (28, 40) | 15 (9, 19) | 0.002 |
| LV mass (g) | 169 (154, 203) | 151 (138, 190) | −12 (−21, −6) | 0.008 |
| TVR (Wood units) | 2.69 (2.23, 3.85) | 1.34 (1.15, 1.87) | −1.17 (−2.06, −0.73) | 0.002 |
| Ea | 2.89 (2.34, 4.00) | 1.50 (1.29, 1.95) | −1.19 (−2.26, 0.53) | 0.002 |
| Ees (sb) | 0.96 (0.75, 1.43) | 0.79 (0.69, 1.11) | −0.10 (−0.35, 0.02) | 0.12 |
| Vo ml | 16 (−14, 38) | −56 (−73, −37) | −70 (−102, −34) | 0.003 |
| Vw | 71.3 (60.2, 90.2) | 61.7 (47.0, 79.0) | −11.9 (−18.1, −4.4) | 0.004 |
| ESV‐100 | 121 (104, 148) | 60 (52, 82) | −54 (−63, −39) | 0.002 |
| Ea/Ees (sb) | 3.08 (2.55, 3.78) | 1.89 (1.75, 2.07) | −1.08 (−1.96, −0.55) | 0.003 |
| Pes/Ves | 0.83 (0.65, 0.95) | 1.52 (1.17, 1.70) | 0.70 (0.35, 0.79) | 0.002 |
| SBMw | 35.1 (24.0, 44.7) | 74.1 (61.5, 77.5) | 31.0 (25.8, 54.2) | 0.002 |
| TCP | 7.4 (3.4, 11.4) | 25.0 (22.7, 33.9) | 19.3 (13.0, 28.9) | 0.002 |
| Ea/[Pes/Ves] | 3.24 (2.65, 4.83) | 1.12 (0.91, 1.4) | 0.54 (0.35, 0.87) | 0.002 |
Median (interquartile range). Ea, arterial elastance (mmHg/mL); Ea/[Pes/Ves], arterial elastance/end‐systolic pressure/end‐systolic volume ratio; Ees (sb), end‐systolic elastance (single‐beat method) (mmHg/mL); ESV‐100, end‐systolic volume at 100 mmHg (mL); LV, left ventricular; LVEDVI, LV end‐diastolic volume index; LVEF, LV ejection fraction; LVESVI, LV end‐systolic volume index; LVSVI, LV stroke volume index; Pes/Ves, end‐systolic pressure/end‐systolic volume ratio; SBMw, slope of preload recruitable stroke work relation (single‐beat method) (erg.cm−3 103); TCP, total circulatory performance (stroke work/end‐diastolic volume/Ea); TVR, total vascular resistance; V0, end‐systolic volume at SBP 0 mmHg (mL); Vw, LV volume at Stroke Work 0.