TABLE 4.
AUC for the CardShock risk score and for the IABP‐SHOCK II score in combination with GDF‐15 or sST2 or both biomarkers to discriminate between in‐hospital survivors and non‐survivors in the elderly (≥75 years old) and in the younger (<75 years old)
| ≥75 years | <75 years | |||||
|---|---|---|---|---|---|---|
| Model | AUC (95% CI) | χ 2 a | P a | AUC (95% CI) | χ 2 a | P a |
| CardShock risk score | 0.75 (0.60–0.91) (n = 40) | 0.82 (0.74–0.90) (n = 106) | ||||
| +GDF‐15 | 0.82 (0.69–0.95) | 4.92 | 0.03 | 0.85 (0.78–0.92) | 4.67 | 0.03 |
| +sST2 | 0.80 (0.66–0.93) | 2.56 | 0.1 | 0.83 (0.76–0.91) | 1.08 | 0.3 |
| +GDF‐15 + sST2 | 0.81 (0.68–0.94) | 5.76 | 0.06 | 0.85 (0.78–0.93) | 4.76 | 0.09 |
| IABP‐SHOCK II score | 0.71 (0.47–0.94) (n = 28) | 0.73 (0.61–0.84) (n = 81) | ||||
| +GDF‐15 | 0.84 (0.69–0.99) | 8.78 | 0.003 | 0.81 (0.71–0.90) | 8.64 | 0.003 |
| +sST2 | 0.78 (0.59–0.96) | 5.14 | 0.02 | 0.79 (0.69–0.89) | 4.75 | 0.03 |
| +GDF‐15 + sST2 | 0.83 (0.68–0.98) | 9.56 | 0.008 | 0.81 (0.72–0.90) | 9.42 | 0.009 |
AUC, area under the curve; CI, confidence interval; GDF‐15, growth differentiation factor‐15; sST2, soluble ST2.
a
χ 2 and P‐values are shown for comparison of nested models.