Region of interest analysis. When moving the affected hand, patients (PBO) showed overactivity in ipsilesional/left vPMC, dPMC, and M1, as well as in contralesional/right SMA, dPMC, and M1 compared with controls. After administration of RBX, the overactivity in ipsilesional/left SMA and vPMC was reduced compared with PBO. Error bars = SEM. *p < 0.05; **p < 0.01. dPMC = dorsal premotor cortex; M1 = primary motor cortex; PBO = placebo; RBX = reboxetine; SEM = standard error of the mean; SMA = supplementary motor area; vPMC = ventral premotor cortex.