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RBX effects on effective connectivity during affected hand movements. The left and right panels demonstrate the modulatory influence induced by affected hand movements in PBO and RBX sessions, respectively. The coupling strength of ipsilesional SMA-M1 significantly increased after administration of RBX compared with PBO (FDR corrected; p < 0.05). FDR = false discovery rate; M1 = primary motor cortex; PBO = placebo; RBX = reboxetine; SMA = supplementary motor area.
