Table 2.
Univariate analysis of factors associated with incomplete response to anti-HER2 neoadjuvant chemotherapy
| pCR |
||||
|---|---|---|---|---|
| Covariate | Level | No N=70 | Yes N=83 | P-value |
| Age | Median | 57 | 53 | 0.006 |
| Range | 30-86 | 26-76 | ||
| Nottingham grade | 1-2 | 29 (43.28) | 38 (56.72) | 0.595 |
| 3 | 40 (47.62) | 44 (52.38) | ||
| Nuclear grade | 2 | 23 (42.59) | 31 (57.41) | 0.568 |
| 3 | 46 (47.42) | 51 (52.58) | ||
| ER positivity | No | 28 (35.9) | 50 (64.1) | 0.013 |
| Yes | 42 (56) | 33 (44) | ||
| PR positivity | No | 36 (36) | 64 (64) | <.001 |
| Yes | 34 (64.15) | 19 (35.85) | ||
| HER2 manual IHC score | 2 | 23 (76.67) | 7 (23.33) | <.001 |
| 3 | 47 (38.21) | 76 (61.79) | ||
| HER2 DIA connectivity | Case # | 70 | 81 | <.001 |
| Median | 0.75 | 0.88 | ||
| Range | 0.12-0.98 | 0.5-0.97 | ||
| HER2 FISH copy number | Case # | 56 | 66 | <.001 |
| Median | 12.46 | 19.9 | ||
| Range | 4-35.5 | 3.6-34.36 | ||
| HER2 FISH ratio | Case # | 56 | 66 | <.001 |
| Median | 4.19 | 7.51 | ||
| Range | 0.96-15.5 | 2.3-22.98 | ||
pCR pathologic complete response, ER estrogen receptor, PR progesterone receptor, DIA digital imaging analysis