FIGURE 1.

Study design: Systematic workflow describing the major steps adopted in this study: (1) collection, curation, and meta-analysis of datasets; (2) identification of differential genes and selecting the genes that encode metalloproteins; (3) genes that encode metalloproteins showing a common trend in the blood and brain were selected and subjected to metalloprotein network; (4) identification of the linker protein that connects the hubs extracted from the metalloprotein network; (5) recruitment of research participants to determine the gene expression linker protein in peripheral blood mononuclear cell (PBMC) and the serum metal concentration of proteins in the hubs.