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. 2021 Mar 15;9:641404. doi: 10.3389/fcell.2021.641404

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Copyright © 2021 Hachim, Elemam, Ramakrishnan, Bajbouj, Olivenstein, Hachim, Al Heialy, Hamid, Busch and Hamoudi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heat map and cosine hierarchical clustering using the expression of the 35-gene signature of samples in the GSE64913 dataset comparing healthy controls (H) to severe asthmatics (SAepithelial brushings obtained from severe asthma patients (N = 17) and healthy volunteers (N = 23). The 35 genes that show a statistically significant differential expression in severe asthmatics compared to healthy are shown on the right panel, while pathways where those genes are enriched significantly are shown on the left panel of the plot. Samples were clustered using Cosine hierarchical clustering. The graph was generated using AltAnalyze software.