. Author manuscript; available in PMC: 2021 Mar 29.

Published in final edited form as: Continuum (Minneap Minn). 2018 Oct;24(5 NEUROINFECTIOUS DISEASE):1397–1421. doi: 10.1212/CON.0000000000000647

TABLE 7-1.

Classification of Human Immunodeficiency Virus–Associated Neurocognitive Disorder Stage^a

	Diagnostic Criteria
HAND Stage	Neuropsychological Testing	Functional Status Assessment
Asymptomatic neurocognitive impairment	Impairment one or more standard deviations below the mean in two or more neurocognitive domains	Does not interfere with daily activities
Mild neurocognitive disorder	Impairment one or more standard deviations below the mean in two or more neurocognitive domains	Mild to moderate interference in daily activities
Human immunodeficiency virus (HIV)–associated dementia	Marked impairment two or more standard deviations below the mean in two or more neurocognitive domains	Marked interference in daily activities

HAND = human immunodeficiency virus–associated neurocognitive disorder.